Carcinogenicity testing of N-hydroxy and other oxidation and decomposition products of 1- and 2-naphthylamine.

Af-Hydroxy-2-naphthylamine produced bladder tumors in three of four dogs when administered over a period of 30 months (dogs were sacrificed 15 months later) in dimethyl sulfoxide solution by repeated instillation directly into the bladders. ./V-Hydroxy-1-naphthylamine was more carcinogenic than TV-hydroxy^-naphthylamine by administration to rats, but the reverse was observed in four experiments with neonatal mice. 2-Amino-l,4-naphthoquinone-A^, 2-naph-